ABSTRACT
Background: The objective of the present study was to compare the changes in serum lipid profile in normal pregnant women with those in patients with pre-eclampsia. Methods: In this study total 140 study subjects were evaluated, 70 normotensive pregnant women as a control group and 70 pre-eclamptic patients as a study group. Study Subjects were between the age group of 20-35 years and in the second and third trimester of pregnancy. Fasting blood samples were collected and serum level of Triglycerides (TG), Total Cholesterol (TC), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), and Very Low Density Lipoprotein (VLDL) were measured by enzymatic colorimetric method. Results: There was a significant rise in TC, TG, LDL and VLDL and significant decrease in HDL level in pre-eclamptic group as compared to normal pregnant women.Conclusion: The findings of the present study are consistent with previous studies suggesting an altered lipid profile has a potential role in the genesis of endothelial dysfunction and expression of pre-eclampsia.